Modeling truncated hemoglobin vibrational dynamics

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Modeling truncated hemoglobin vibrational dynamics.

We present a study on the near equilibrium dynamics of two small proteins in the family of truncated hemoglobins, developed under the framework of a Gaussian network approach. Effective beta carbon atoms are taken into account besides Calphas for all residues but glycines in the coarse-graining procedure, without leading to an increase in the degrees of freedom (beta Gaussian Model). Normalized...

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Introduction A wide diversity in both structure and function has been discovered in the study of hemoglobins (Hbs) from many species. Hemoglobins play oxygen transport in red blood cells in higher organisms. Even though oxygen molecule can diffuse into the cell, unicellular organisms also have hemoglobin-like molecules [1]. Truncated hemoglobins (trHbs) are distributed from bacteria to unicellu...

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ژورنال

عنوان ژورنال: Proteins: Structure, Function, and Bioinformatics

سال: 2005

ISSN: 0887-3585

DOI: 10.1002/prot.20707